It does not appear to be it, but you do not have any spaces any where larger in the file hierarchy? in all probability not because this is the only file it complains about, but You can not have any Areas in the path nonetheless.
Also, I don't know why Questa is contemplating the MIF file for being a 'VHDL', as I am not deliberately specifying the MIF any where in my challenge as a VHDL file.
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The crystal buildings of your MIF-inhibitor complexes had been used since the First templates for Digital screening. The Protein Preparation Wizard module in Schrödinger was utilised to get ready Just about every MIF complex. The ligand located while in the Lively web site between chains A and B was taken care of. The complex was then refined Along with the OPLS force subject [26]. Pro1, a significant nucleophilic residue, was protonated In line with experimental and theoretical final results [27].